Table 3.

Association of staging classification with increased risk of mortality and hospitalization

Variables	All-cause mortality (86 events)				Hospitalization for cardiovascular cause or cardiac mortality (57 events)
	Univariable analysis		Multivariable analysis		Univariable analysis		Multivariable analysis
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Stage of cardiac damage (per one-stage increase)	1.68 (1.26-2.23)	<0.001	1.41 (1.07-1.85)	0.015	1.65 (1.13-2.40)	0.009	1.51 (1.07-2.15)	0.020
EuroSCORE II	1.53 (1.34-1.75)	<0.001	1.36 (1.18-1.58)	<0.001	1.53 (1.29-1.84)	<0.001	1.36 (1.11-1.65)	0.002
Hypertension	1.73 (1.10-2.70)	0.02	1.45 (0.90-2.34)	0.12	1.77 (0.99-3.14)	0.053	1.47 (0.79-2.74)	0.22
Obesity	1.22 (0.49-3.00)	0.67	-	-	4.00 (0.55-29.02)	0.17	-	-
Coronary artery disease	1.08 (0.47-2.48)	0.86	-	-	1.62 (0.64-4.08)	0.31	-	-
History of stroke	3.42 (1.75-6.66)	<0.001	1.99 (0.98-4.05)	0.06	3.23 (1.36-7.66)	0.008	1.73 (0.69-4.37)	0.24
MR severity	2.01 (1.30-3.10)	0.002	2.05 (1.25-3.38)	0.005	1.34 (0.76-2.37)	0.32	1.40 (0.72-2.72)	0.32
Mitral valve intervention (as time-dependent variable)	0.40 (0.24-0.67)	<0.0001	0.41 (0.24-0.71)	0.002	0.22 (0.10-0.50)	<0.001	0.21 (0.09-0.50)	<0.001

Notes. Bold indicates statistical significance.

Abbreviations as in Tables 1 and 2. CI = confidence interval, HR = hazard ratio.