Table 2.
Six Month Treatment Effects on Body Composition Metrics.
| Outcome Measures | Risedronate | Placebo | |||||
|---|---|---|---|---|---|---|---|
| n | Six Month | Six Month Δ | n | Six Month | Six Month Δ | p | |
| Body mass (kg) | 8 | 99.3 (95.6, 103.1) | −16.3 (−20.0, −12.5) | 13 | 94.7 (91.9, 97.5) | −20.9 (−23.7, −18.1) | .057 |
| BMI (kg/m2) | 8 | 37.2 (35.8, 38.7) | −6.1 (−7.5, −4.6) | 13 | 35.7 (34.7, 36.7) | −7.6 (−8.6, −6.6) | .095 |
| DXA-Acquired Measures | |||||||
| Total Fat Mass (kg) | 8 | 45.6 (41.8, 49.4) | −12.4 (−16.2, −8.6) | 13 | 40.6 (37.9, 43.4) | −17.3 (−20.1, −14.6) | .048 |
| Percent Fat Mass (%) | 8 | 46.2 (43.1, 49.2) | −3.9 (−7.0, −0.8) | 13 | 42.1 (39.8, 44.5) | −7.9 (−10.3, −5.6) | .045 |
| Total Lean Mass (kg) | 8 | 50.4 (49.1, 51.8) | −3.2 (−4.5, −1.9) | 13 | 50.7 (49.7, 51.7) | −2.9 (−3.9, −1.9) | .745 |
| Appendicular Lean Mass (kg) | 8 | 23.1 (22.0, 24.2) | −1.2 (−2.3, −0.1) | 13 | 22.2 (21.4, 23.1) | −2.1 (−3.0, −1.2) | .202 |
| Appendicular Lean Mass Index (kg/m2) | 8 | 8.6 (8.2, 9.0) | −0.4 (−0.8, −0.0) | 13 | 8.3 (8.0, 8.6) | −0.8 (−1.1, −0.4) | .212 |
| Lean-to-Fat Ratio | 8 | 1.2 (1.0, 1.3) | 0.2 (0.1, 0.3) | 13 | 1.3 (1.2, 1.4) | 0.4 (0.3, 0.5) | .054 |
| CT Acquired Measures | |||||||
| Total Trunk Muscle CSA (cm2) | 8 | 126.9 (121.1, 132.6) | −10.2 (−15.9, −4.4) | 12 | 120.6 (115.7, 125.4) | −16.5 (−21.3, −11.6) | .098 |
| Skeletal Muscle Index (cm2/m2) | 8 | 49.6 (47.3, 51.8) | −4.0 (−6.2, −1.7) | 12 | 47.1 (45.2, 49.0) | −6.4 (−8.3, −4.5) | .098 |
| Total Trunk Muscle Attenuation (HU) | 8 | 35.5 (33.2, 37.9) | −3.6 (−5.9, −1.3) | 12 | 36.2 (34.4, 38.1) | −2.9 (−4.7, −1.0) | .633 |
| Mid-Thigh Muscle CSA (cm2) | 8 | 99.4 (93.9, 104.9) | −5.5 (−11.0, 0.1) | 12 | 92.5 (87.8, 97.2) | −12.4 (−17.1, −7.7) | .067 |
| Mid-Thigh Muscle Attenuation (HU) | 8 | 37.5 (35.0, 39.9) | −0.3 (−2.8, 2.2) | 12 | 38.2 (36.1, 40.3) | 0.4 (−1.6, 2.5) | .638 |
Group treatment effect and difference estimates from a mixed model using contrast statements at 6 months adjusted for baseline values of each outcome
BMI: Body Mass Index; CSA: Cross-Sectional Area; HU: Hounsfield Units