Table 3:
12 Month Treatment Effects on Body Composition Metrics.
| Outcome Measures | Risedronate | Placebo | |||||
|---|---|---|---|---|---|---|---|
| n | 12-Month | 12-Month Δ | n | 12-Month | 12-Month Δ | p | |
| Body mass (kg) | 5 | 101.7 (95.4, 108.0) | −13.9 (−20.2, −7.6) | 9 | 95.6 (90.9, 100.3) | −20.0 (−24.6, −15.3) | .121 |
| BMI (kg/m2) | 5 | 38.4 (35.9, 40.8) | −4.9 (−7.4, −2.5) | 9 | 36.1 (34.3, 37.9) | −7.2 (−9.0, −5.4) | .130 |
| DXA-Acquired Measures | |||||||
| Total Fat Mass (kg) | 5 | 47.0 (41.4, 52.6) | −11.0 (−16.6, −5.4) | 9 | 42.1 (38.0, 46.2) | −15.9 (−20.0, −11.7) | .163 |
| Percent Fat Mass (%) | 5 | 46.7 (42.7, 50.7) | −3.4 (−7.4, 0.6) | 9 | 43.2 (40.1, 46.2) | −6.9 (−10.0, −3.9) | .162 |
| Total Lean Mass (kg) | 5 | 51.8 (50.0, 53.5) | −1.9 (−3.6, −0.1) | 9 | 50.2 (48.8, 51.5) | −3.5 (−4.8, −2.1) | .141 |
| Appendicular Lean Mass (kg) | 5 | 23.9 (22.8, 24.9) | −0.5 (−1.5, 0.6) | 9 | 21.5 (20.7, 22.3) | −2.9 (−3.6, −2.1) | .001 |
| Appendicular Lean Mass Index (kg/m2) | 5 | 9.0 (8.6, 9.4) | −0.1 (−0.5, 0.3) | 9 | 8.0 (7.7, 8.3) | −1.0 (−1.3, −0.7) | .001 |
| Lean-to-Fat Ratio | 5 | 1.2 (1.0, 1.4) | 0.2 (0.0, 0.4) | 9 | 1.3 (1.1, 1.4) | 0.3 (0.2, 0.5) | .342 |
| CT Acquired Measures | |||||||
| Total Trunk Muscle CSA (cm2) | 4 | 129.2 (122.4, 135.9) | −7.9 (−14.6, −1.1) | 8 | 122.2 (116.9, 127.6) | −14.8 (−20.1, −9.5) | .111 |
| Skeletal Muscle Index (cm2/m2) | 4 | 50.5 (47.8, 53.1) | −3.1 (−5.7, −0.4) | 8 | 47.7 (45.7, 49.8) | −5.8 (−7.9, −3.7) | .111 |
| Total Trunk Muscle Attenuation (HU) | 4 | 34.9 (31.9, 37.9) | −4.2 (−7.2, −1.2) | 8 | 37.0 (34.8, 39.3) | −2.1 (−4.4, 0.1) | .259 |
| Mid-Thigh Muscle CSA (cm2) | 4 | 102.8 (95.8, 109.8) | −2.1 (−9.0, 4.9) | 8 | 95.0 (89.2, 100.9) | −9.8 (−15.6, −4.0) | .095 |
| Mid-Thigh Muscle Attenuation (HU) | 4 | 36.4 (34.2, 38.7) | −1.3 (−3.6, 1.0) | 8 | 38.4 (36.5, 40.3) | 0.6 (−1.3, 2.5) | .183 |
Group treatment effect and difference estimates from a mixed model using contrast statements at 12 months adjusted for baseline values of each outcome
BMI: Body Mass Index; CSA: Cross-Sectional Area; HU: Hounsfield Units