Table 1. Clinical characteristics of enterovirus-associated severe neonatal infections of male neonates with acute liver failure and multivisceral failure, France, 2022–2023 (n  =  9).

Patient number	Gestation length (weeks + days)	Date of birth	Mode of delivery	Birth weight (g)	Age at first symptoms (days)	Specimen type	Age at diagnosis of EV infection (days)	Maternal EV infection	Maternal EV infection (days from delivery)	Treatment	Dialysis	Age at death (days)
1a	39 + 0	Jan 2023	Vaginal	3,480	5	CSF	5	Yes	0	Pocapavir D7-D21 IVIg D5	Yes	34
2	35 + 4	Dec 2022	Caesarian	2,400	5	Blood	5	Yes	-3b	IVIg D7, D8	Yes	19
3				2,650		Blood				IVIg D7, D8	Yes	40
4	31 + 5	Oct 2022	Vaginal	1,805	5	Blood	6	NA	NA	No	No	7
5				2,320		Post-mortem biopsies				No	No	6
6	36 + 3	Jul 2022	Vaginal	2,600	3	CSF	3	Yes	-3b	IVIg D4	No	5
7				2,860		CSF				IVIg D3, D4	No	5
8	34 + 0	Mar 2023	Vaginal	2,375	4	CSF	8	Yes	-1b	Pocapavir D8-D23 IVIg D18, 19	No	NA
9				1,970		CSF				Pocapavir D8-D23 IVIg D18, 19	No	NA

CSF: cerebrospinal fluid; IVIg: polyvalent intravenous immunoglobulins; NA: not applicable.

^a From a singleton pregnancy.

^b Days before delivery.