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. 2023 Jun 1;220(9):e20221751. doi: 10.1084/jem.20221751

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© 2023 Moutsopoulos et al.

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Figure 5. — Levels of NET complexes in GCF and serum correlate with severity of periodontitis. (A) Human GCF samples were analyzed for the levels of Car–dsDNA complexes, Car-H4, citH3–dsDNA complex, and NE activity in HC (n = 10) and periodontitis (perio) patients (n = 10). (B) Serum samples were analyzed to quantify the levels of Car–dsDNA, Car-H3, citH3–dsDNA complex, NE activity, and absolute neutrophils number in HC and perio patients. (C) Correlation analysis of CAL (in mm) with GCF levels of Car-H4 and elastase activity or serum levels of Car-H3 measured in periodontitis patients. (D) Correlation between plasma levels of Car–dsDNA complexes and Car-H3 measured in periodontitis patients. Results are expressed as OD index. Data are representative of three (A and B) independent experiments. Graphs show the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001****P < 0.0001. Unpaired t test (A and B).