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. 2023 May 15;15(5):700–712. doi: 10.4251/wjgo.v15.i5.700

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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A case of poor response confirmed at pathology (ypT2N0). A-C: A 42-year-old male with rectal cancer. Endoscopy (A) and MRI (B and C) staged a tumour of the middle rectum (cT3bN2, mesorectal fascia negative, extramural vascular invasion positive, pelvic nodes negative). The patient underwent total neoadjuvant therapy; D-F: Restaging at 20 wk after the beginning of neoadjuvant radiotherapy showed a poor response at endoscopy (D) and MRI (E and F).