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. 2023 May 16;11(14):3288–3294. doi: 10.12998/wjcc.v11.i14.3288

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Pedigree of the patient and mutation analysis of the SPG4 gene. A: The family with hereditary spastic paraplegia (HSP). The proband is indicated by an arrow. A square indicates male, a circle for female, a shadow symbol for an HSP individual, including a black shadow for a symptomatic patient and a gray shadow for an asymptomatic patient, a non-shadowing symbol for a non-HSP individual, and a slash symbol for a deceased individual; B: Sequence analysis identified a c. 1053dupA mutation in the SPG4 gene in this family. Black frames delineate the C. 1053dupA nucleotides; and C: Wild-type sequence.