FIGURE 7.

Inhibited IF transport causes aggregation in the absence of gigaxonin. In wild type, IF will be actively transported along microtubules by the kinesin‐1 motor. An unknown adaptor might aid the interaction between kinesin and IF. Besides transport, IF undergoes constant rearrangement by assembly and disassembly process by which soluble IF oligomers are released into the cytosol. Fraction of these soluble oligomers binds to gigaxonin and undergoes proteasomal degradation. Thereby, gigaxonin regulates the IFs turnover. Absence of gigaxonin protein leads to the accumulation of soluble IFs in the cytosol. Accumulated soluble IFs sequester the unknown adaptor which links kinesin to IF. Thereby, block the IF interaction with kinesin‐1 motor and inhibit IF transport in a dominant‐negative manner.