FIGURE 3.

Social genomics in healthcare. To reduce patients’ risk for negative health and behavioral outcomes, health care providers can screen for and respond to factors that have been associated with the Conserved Transcriptional Response to Adversity (CTRA). These factors include loneliness, social isolation, interpersonal conflict, violence, abuse, neglect, adverse childhood experiences, and lifetime stressor exposure. Responding to these factors can involve engaging in trauma- and resilience-informed care, and prescribing evidence-based interventions that can reduce the CTRA, such as cognitive-behavior therapy, mindfulness meditation, stress management, engaging in prosocial behaviors, maternal warmth/supportive parenting programs, and enhancing in-person social connection.