Fig. 4.

Pseudovirus neutralizing antibody titers over time in study participants who received two doses of study intervention. Box plots and individual plots of nAb antibody titers over time in participants who received AZD1222 or placebo (on Days 1 and 29) and had not been censored at the time of study visits, as determined by pseudovirus neutralization assay. The pooled placebo arm includes all participants who received two doses of placebo; participants who received two doses of AZD1222 are stratified by age. The bottom and top edges of the box indicate the first and third quartiles [the difference is the IQR], the line is the median, and the diamond mark is the geometric mean. The whiskers that extend from the box indicate the minimum and maximum within the range of 1.5 × IQR from the box. Box plots are created using log-transformed values. Titer values measured as below the LLoQ (40) are imputed to a value that is half of the LLoQ. Titer values measured as above the ULoQ (787,339) are imputed at the ULoQ value. Abbreviations: IQR = interquartile range, LLoQ = lower limit of quantification, nAb = pseudovirus neutralizing antibodies, ULoQ = upper limit of quantification.