Figure 2.

hSOD1-G93A mice have reduced quantal content (QC) and mEPP frequency at 16 weeks old, and increased EPP rise time at 12 weeks. (A) QC increased with age in hSOD1-G93A mice and their wildtype counterparts over most of the developmental time course. It briefly reduced at 16 weeks old (***p < 0.001, Two-way ANOVA – Bonferroni post-test), but recovered again by early symptomatic stages. (B) mEPP frequency increased with age until 8 weeks, then stabilized in WT NMJs. At hSOD1-G93A NMJs, mEPP frequency was normal until 16 weeks, when it was transiently reduced (**p < 0.01, Two-way ANOVA – Bonferroni post-test).