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. 2023 Mar 15;147(23):1734–1744. doi: 10.1161/CIRCULATIONAHA.122.060002

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© 2023 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Progerin level is associated with survival. Risk of death incrementally decreased with lower plasma progerin (P<0.0001) using time-dependent joint modeling. Change in mortality risk (y axis) versus all values in range of observed progerin decrease (x axis) from 0 to 65 000 pg/mL. Solid line is % decrease in risk if death; dashed lines = 95% CI. Median decrease=15 186 pg/mL (Q1;Q3=19 826;9281). n=74 subjects (9 untreated with single samples and 65 treated with untreated baseline plus multiple on-therapy samples).