Table 1. Patient demographic, laboratory, and clinical characteristics.
| Total Cases | Activated T-cell hepatitis | Indeterminate PALF | P value | |
|---|---|---|---|---|
| n = 8 | n = 4 | n = 4 | ||
| At Study Enrollment | ||||
| Age, years | 6.5 (3.0–12.3) | 4.0 (3.0–7.0) | 10.0 (6.3–12.8) | 0.63 |
| Gender, male | 4 (50) | 2 (50) | 2 (50) | >0.99 |
| Symptoms prior to admission, weeks | 2.0 (0.9–3.0) | 3.0 (2.8–3.0) | 0.8 (0.5–1.3) | 0.06 |
| Hepatic encephalopathy level 0–1 | 5 (63) | 3 (75) | 2 (50) | >0.99 |
| Alanine aminotransferase (IU/L) | 2167 (1279–5317) | 1576 (1276–1965) | 6545 (3303–9800) | 0.20 |
| Total bilirubin (mg/dL) | 14.6 (3.3–18.5) | 18.6 (17.5–19.8) | 2.6 (1.1–6.6) | 0.03 |
| International normalized ratio | 2.1 (2.1–2.3) | 2.1 (2.0–2.1) | 2.3 (2.1–3.0) | 0.48 |
| Total white blood cell count (1000/mm3) | 4.0 (3.2–8.0) | 3.0 (2.2–4.9) | 6.1 (4.2–9.6) | 0.20 |
| Hemoglobin (g/dL) | 11.2 (10.2–12.7) | 10.6 (10.2–11.6) | 11.9 (10.8–12.8) | 0.68 |
| Platelet count (1000/mm3) | 183 (150–242) | 183 (150–218) | 199 (131–256) | >0.99 |
| Worst values during admission | ||||
| Hepatic encephalopathy level 2–4 | 4 (50) | 2 (50) | 2 (50) | >0.99 |
| Highest alanine aminotransferase (IU/L) | 2381 (1513–7249) | 1876 (1513–2249) | 7833 (5283–9988) | 0.34 |
| Highest total bilirubin (mg/dL) | 20.4 (4.1–22.1) | 21.6 (20.4–22.6) | 3.2 (1.1–9.2) | 0.11 |
| Highest international normalized ratio | 2.3 (2.2–2.5) | 2.3 (2.2–2.4) | 2.3 (2.2–3.0) | 0.86 |
| Lowest total white blood cell count (1000/mm3) | 1.7 (1.3–3.7) | 1.7 (1.3–5.5) | 1.9 (1.3–3.7) | >0.99 |
| Lowest hemoglobin (g/dL) | 10.3 (7.5–11.4) | 10.3 (9.4–11.0) | 9.2 (7.3–11.6) | 0.89 |
| Lowest platelet count (1000/mm3) | 95 (48–179) | 140 (100–179) | 60 (44–115) | 0.68 |
| Outcome and follow up | ||||
| Duration of admission, days | 12.0 (7.8–16.3) | 9.0 (7.8–11.3) | 13.5 (6.3–18.5) | 0.48 |
| Admission to normal liver enzymes, days | 92.0 (57.5–107.0) | 110.0 (92.0–130.0) | 52.0 (39.5–72.3) | 0.11 |
| Developed aplastic anemia | 2 (25) | 2 (50) | 0 | 0.43 |
aData are medians (interquartile range) or n (%).