Table 1.

Available software applications to implement the existing phase I drug-combination trial designs.

Designs	Software	Next dose recommendation*	Protocol template included	Ease of implementation
3+3	No
Copula	Executable	No	No	Easy
POCRM	R package	Yes	No	Need R skills
	Web app	No	Yes	Easy
BLRM	R package	Yes	No	Need R skills
	EAST appa	Yes	No	Easy
BOIN	R package	Yes	No	Need R skills
	Web app	Yes	Yes	Easy
	Desktop app	Yes	Yes	Easy
Waterfall	R package	Yes	No	Need R skills
	Web app	Yes	Yes	Easy
	Desktop app	Yes	Yes	Easy
PIPE	R package	Yes	No	Need R skills
	EAST appa	Yes	No	Easy

Note:

^*The function to obtain the dose assignment for the next new patient when conducting the trial.

^aA commercial software developed by Cytel, other applications are freely available. All the listed software applications can obtain the design operating characteristics via simulations. Website URLs for the software applications are provided in Table S2 of Supplementary Materials.