Table 2.

Average computation time needed for each design to simulate 2000 trials.

Design	3+3	BLRM	POCRN	Copula	BOIN	PIPE	Waterfall
2 × 4 combination trials with 27 patients
Time (min)	0.01	131.4	8.1	92.7	0.05	1.9	0.9
2 × 4 combination trials with 36 patients
Time (min)	0.01	192.7	12.2	140.0	0.06	2.4	0.9
3 × 5 combination trials with 48 patients
Time (min)	0.02	456.7	16.2	302.0	0.07	9.5	0.9
4 × 4 combination trials with 48 patients
Time (min)	0.02	498.6	16.9	352.1	0.08	11.8	1.0

Note: Dose-assignment decisions for each design were updated after three patients have been treated. The average computation time is recorded using 2000 different jobs (i.e., scenarios) based on Red Hat Enterprise Linux high-throughput computing cluster with the processor speed ranging from 2.00 GHz to 2.67 GHz. Each job requires one node, one processor core, and one gigabyte memory per node.