Table 2. Respiratory physiology.
| All (n = 100) | COVID-19 ARDS (n = 50) | Non-COVID-19 ARDS (n = 50) | p-value | |
|---|---|---|---|---|
| ARDSe severity, n (%) | 0.888 | |||
| Mild | 24 (24.0) | 11 (22.0) | 13 (26.0) | |
| Moderate | 56 (56.0) | 29 (58.0) | 27 (54.0) | |
| Severe | 20 (20.0) | 10 (20.0) | 10 (20.0) | |
| Progression | 0.884 | |||
| Progress to moderate, n (%) | 13 (13.0) | 6 (12.0) | 7 (14.0) | |
| Progress to severe, n (%) | 26 (26.0) | 14 (28.0) | 12 (24.0) | |
| PaO2/FiO2 ratio, mmHg | 146.6 (106.4–197.7) | 142.4 (105.2–189.4) | 153.3 (116.2–210.8) | 0.198 |
| PaO2, mmHg | 127.7 (89.4–181.6) | 132.9 (88.4–186.0) | 126.6 (89.9–179.7) | 0.931 |
| FiO2, % | 100.0 (80.0–100.0) | 100.0 (85.0–100.0) | 100.0 (80.0–100.0) | 0.287 |
| pH | 7.36 (7.32–7.44) | 7.37 (7.32–7.44) | 7.36 (7.33–7.44) | 0.684 |
| PaCO2, mmHg | 39.2 (33.7–44.6) | 39.4 (34.5–43.5) | 37.9 (33.5–44.7) | 0.899 |
| VT, ml/kg PBWf | 7.87 (7.08–8.70) | 7.63 (7.05–8.48) | 7.96 (7.08–8.79) | 0.277 |
| Minute ventilation, L/min | 9.1 (6.9–10.9) | 8.5 (6.7–10.3) | 9.3 (7.9–11.6) | 0.110 |
| PEEPg, cmH2O | 10.0 (8.0–12.0) | 10.0 (8.0–12.0) | 8.0 (8.0–10.0) | 0.008 |
| Plateau pressure, cmH2O | 24.0 (21.0–28.0) | 26.0 (22.0–30.0) | 22.0 (20.0–26.0) | 0.005 |
| Driving pressure, cmH2O | 15.0 (13.0–18.4) | 15.0 (13.0–20.0) | 14.5 (12.0–18.0) | 0.511 |
| Static compliance, ml/cmH2O | 34.0 (25.5–43.0) | 32.2 (24.0–38.5) | 35.2 (27.0–44.8) | 0.082 |
| Mean airway pressure, cmH2O | 14.0 (12.0–16.1) | 15.0 (13.0–16.9) | 13.5 (11.0–16.0) | 0.060 |
| Ventilatory ratio | 1.61 (1.32–1.95) | 1.53 (1.23–1.85) | 1.74 (1.38–2.07) | 0.052 |
| Adjunctive therapy, n (%) | ||||
| Prone positioning | 34 (34.0) | 29 (58.0) | 5 (10.0) | <0.001 |
| Recruitment maneuvers | 22 (22.0) | 18 (36.0) | 4 (8.0) | 0.001 |
| Inhaled Nitric Oxide | 8 (8.0) | 0 (0.0) | 8 (16.0) | 0.006 |
| ECMOh | 2 (2.0) | 1 (2.0) | 1 (2.0) | 1.000 |
e ARDS, acute respiratory distress syndrome
f PBW, predicted body weight
g PEEP, positive end-expiratory pressure
h ECMO, extracorporeal membrane oxygenation