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. 2023 May 22;19(5):e1010693. doi: 10.1371/journal.pgen.1010693

Fig 2. Boulder plot of pAUDIT (top) and GAD (bottom) interaction association p-values using imputed transcription.

Fig 2

Shown are the results from the final meta-analysis of all data. In these plots, each interaction test is indicated by two points, located at their physical chromosomal positions. Pairs with significant interactions are connected by lines. Peaks, such as the peak on Chromosome 19 in the top figure, indicate strong interactions with many other genes, i.e., a hub gene (see Fig 3 as well). Black lines connect pairs that surpassed p<5.86e-10 in the discovery cohort (UKB), green and blue lines connect pairs of loci with FDR q<0.05 or nominally significant interaction (p<0.05) in the replication cohort, and gray lines connect pairs of genes with p<2.5e-10 in the final meta-analysis. For clarity, only interaction associations with p<1e-5 are shown. Numerical results of genes reaching significance are presented in Table 1.