Scheme 2.

Reagents and reaction conditions: a) 3-Iodothioanisole, Pd(OAc)₂, Cs₂CO₃, PPh₃, anhydrous DMF, 80°C, 12 h, 40%; b) Oxone, MeOH, H₂O, rt, 16 h, 78%; c) BBr₃, anhydrous CH₂Cl₂, -78°C, 1 h; rt, overnight, 40%; d) triethylamine, appropriate sulfonyl chloride derivative, anhydrous DMF, 0°C then rt, 2 h; e) appropriate sulfamoyl chloride derivative, anhydrous DMAc, 0°C then rt, overnight (compounds 2h,i); piperidine-1-sulfonyl chloride, NaH, anhydrous DMAc, 0°C then rt, overnight (compounds 2j).