Table 1. Urease inhibition of sulfonate and sulfamate derivatives (1a-1j and 2a-2j).
| Compound No. | Potency against urease IC50 ± SEM (μM)a |
|---|---|
| 1a | 4.10 ± 0.03 |
| 1b | 4.01 ± 0.11 |
| 1c | 4.04 ± 0.09 |
| 1d | 3.09 ± 0.07 |
| 1e | 4.30 ± 0.01 |
| 1f | 5.17 ± 0.01 |
| 1g | 3.22 ± 0.06 |
| 1h | 2.96 ± 0.02 |
| 1i | 5.51 ± 0.17 |
| 1j | 6.97 ± 0.09 |
| 2a | 5.01 ± 0.03 |
| 2b | 4.97 ± 0.11 |
| 2c | 2.94 ± 0.05 |
| 2d | 4.46 ± 0.12 |
| 2e | 5.21 ± 0.03 |
| 2f | 7.19 ± 0.09 |
| 2g | 5.59 ± 0.04 |
| 2h | 4.72 ± 0.13 |
| 2i | 4.74 ± 0.21 |
| 2j | 5.82 ± 0.02 |
a The results are expressed as means of triplicate assays ± SEM.