Table 2.
Blood pressure by visit according to the groups formed by antihypertensive added at certain visit (the data are presented as median and interquartile range in parenthesis.
| Visit | Blood pressure | No antihypertensive added | 1st line antihypertensive added | Spironolactone added | Central antihypertensive added | Spironolactone + central antihypertensive added | Probability of null hypothesis (p) |
|---|---|---|---|---|---|---|---|
| Baseline | No of patients prescribed with add-on drug at baseline | n = 387 | n = 61 | n = 60 | n = 7 | n = 0 | |
| Systolic–office | 156.6 [14.0] | 158.3 [11.7] | 161.0 [19.0] | 153.0 [18.8] | - | 0.310 | |
| Systolic–home | 156.8 [17.0]* | 162.2 [12.8] | 163.3 [16.2]* | 155.6 [9.0] | - | 0.000* | |
| Diastolic–office | 94.7 [7.7] | 95.0 [8.1] | 93.3 [10.0] | 90.0 [10.7] | - | 0.647 | |
| Diastolic–home | 95.0 [6.8] | 97.3 [8.3]* | 95.7 [10.1] | 93.0 [4.7]* | - | 0.018* | |
| Heart rate at office | 76.7 [12.7] | 76.2 [10.1] | 75.7 [13.1] | 73.3 [16.7] | - | 0.737 | |
| Heart rate at home | 78.0 [12.9] | 78.3 [9.6] | 78.8 [11.7] | 80.4 [18.1] | - | 0.729 | |
| Visit 1 | No of patients prescribed with add-on drug at visit 1 | n = 49 | n = 29 | n = 417 | n = 15 | n = 5 | |
| Systolic–office | 145.0 [18.0] | 143.0 [12.8] | 150.1 [22.3] | 137.2 [24.2] | - | 0.166 | |
| Systolic–home | 146.3 [18.2]* | 152.2 [16.5] | 151.7 [21.3]* | 141.2 [20.9] | - | 0.003* | |
| Diastolic–office | 90.0 [9.2] | 90.0 [7.3] | 87.7 [10.3] | 86.7 [20.0] | - | 0.789 | |
| Diastolic–home | 90.0 [9.9]* | 92.8 [8.2]* | 87.7 [14.4] | 82.8 [17.4] | - | 0.017* | |
| Heart rate at office | 74.7 [10.6] | 73.8 [7.7] | 74.3 [8.7] | 69.7 [15.0] | - | 0.665 | |
| Heart rate at home | 75.2 [10.8] | 76.2 [8.2] | 75.2 [9.7] | 74.5 [16.2] | - | 0.869 | |
| Visit 2 | No of patients prescribed with add-on drug at visit 2 | n = 26 | n = 21 | n = 447 | n = 14 | n = 7 | |
| Systolic–office | 143.3 [22.7] | 142.5 [19.6] | 137.0 [15.7] | 134.2 [28.9] | 131.2 [20.0] | 0.083 | |
| Systolic–home | 144.3 [18.3] | 144.7 [18.6] | 138.0 [15.1] | 136.6 [20.8] | 135.1 [17.3] | 0.061 | |
| Diastolic–office | 88.3 [10.0] | 86.7 [9.5] | 85.0 [10.0] | 82.8 [10.3] | 83.3 [12.5] | 0.051 | |
| Diastolic–home | 87.2 [10.5] | 87.1 [9.5] | 85.4 [10.1] | 83.8 [15.4] | 78.1 [17.7] | 0.135 | |
| Heart rate at office | 78.3 [10.5]* | 70.7 [7.3]* | 72.0 [8.3] | 73.0 [8.9] | 73.3 [14.0] | 0.006* | |
| Heart rate at home | 77.0 [9.9] | 71.7 [9.7] | 73.3 [8.5] | 71.8 [7.1] | 71.6 [19.2] | 0.062 | |
| Visit 3 | No of patients prescribed with add-on drug at visit 3 | n = 19 | n = 16 | n = 457 | n = 12 | n = 11 | |
| Systolic–office | 139.2 [23.6] | 139.2 [14.7] | 133.3 [13.3] | 133.3 [25.5] | 128.3 [11.7] | 0.117 | |
| Systolic–home | 137.9 [16.9] | 139.8 [15.1] | 135.6 [13.8] | 131.9 [19.7] | 131.7 [9.7] | 0.272 | |
| Diastolic–office | 83.3 [10.0] | 83.3 [8.3] | 82.7 [8.2] | 82.0 [13.7] | 80.0 [15.7] | 0.357 | |
| Diastolic–home | 86.8 [13.4] | 84.5 [8.0] | 83.2 [8.9] | 82.6 [18.6] | 76.5 [11.8] | 0.106 | |
| Heart rate at office | 74.0 [7.8] | 72.3 [11.7] | 71.7 [9.0] | 73.3 [11.3] | 68.7 [17.0] | 0.827 | |
| Heart rate at home | 74.6 [10.0] | 74.3 [8.0] | 72.5 [8.4] | 69.4 [6.8] | 68.2 [7.4] | 0.206 | |
| Visit 4 | No of patients prescribed with add-on drug at visit 4 | n = 14 | n = 16 | n = 459 | n = 13 | n = 13 | |
| Systolic–office | 131.7 [21.7] | 133.3 [10.7] | 132.7 [13.3] | 130.0 [22.0] | 123.3 [16.7] | 0.069 | |
| Systolic–home | 132.9 [18.9] | 137.5 [10.8] | 133.2 [11.6] | 134.2 [20.0] | 130.0 [7.7] | 0.280 | |
| Diastolic–office | 83.3 [13.3] | 87.7 [11.7] | 81.7 [7.3] | 83.3 [9.7] | 76.7 [11.7]* | 0.025* | |
| Diastolic–home | 84.6 [14.7] | 84.8 [9.1] | 82.2 [8.3] | 83.0 [8.3] | 73.7 [7.9]* | 0.001* | |
| Heart rate at office | 71.3 [13.7] | 69.3 [9.0] | 71.7 [8.3] | 70.7 [9.7] | 67.7 [12.7] | 0.317 | |
| Heart rate at home | 71.4 [8.7] | 72.0 [7.3] | 72.3 [7.8] | 70.7 [5.1] | 69.4 [9.9] | 0.346 | |
| Visit 5 | No of patients prescribed with add-on drug at visit 5 | n = 13 | n = 16 | n = 460 | n = 10 | n = 16 | |
| Systolic–office | 126.2 [12.6] | 130.8 [10.4] | 130.7 [11.7] | 138.3 [21.0] | 128.7 [13.0] | 0.056 | |
| Systolic–home | 129.0 [12.6] | 132.4 [10.9] | 131.8 [10.8] | 134.9 [18.4] | 129.0 [9.5] | 0.391 | |
| Diastolic–office | 79.3 [4.1] | 83.8 [4.2] | 80.3 [7.3] | 83.3 [9.3] | 76.7 [12.0] | 0.069 | |
| Diastolic–home | 79.6 [5.8] | 84.1 [7.3] | 81.2 [7.6] | 84.7 [7.6] | 74.7 [14.0] | 0.030 | |
| Heart rate at office | 72.0 [12.7] | 70.3 [7.4] | 71.3 [8.3] | 70.7 [10.3] | 66.7 [12.8] | 0.586 | |
| Heart rate at home | 70.0 [8.0] | 72.5 [9.6] | 71.3 [7.6] | 69.2 [13.1] | 69.6 [9.3] | 0.472 | |
| Visit 6 | No of patients prescribed with add-on drug at visit 6 | n = 13 | n = 16 | n = 460 | n = 10 | n = 16 | |
| Systolic – office | 122.5 [7.5] | 128.5 [18.3] | 129.3 [10.7] | 131.7 [14.9] | 130.7 [15.0] | 0.078 | |
| Systolic–home | 125.9 [8.3] | 129.1 [10.7] | 129.7 [9.4] | 128.9 [12.7] | 128.6 [12.6] | 0.246 | |
| Diastolic–office | 79.2 [4.6] | 80.7 [5.0] | 80.0 [5.3] | 83.3 [8.2] | 80.0 [16.7] | 0.370 | |
| Diastolic–home | 78.6 [8.8] | 80.7 [7.3] | 80.1 [6.9] | 84.1 [6.8] | 75.9 [19.5] | 0.170 | |
| Heart rate at office | 71.0 [11.8] | 69.0 [7.2] | 70.7 [8.3] | 71.2 [10.4] | 71.7 [16.0] | 0.819 | |
| Heart rate at home | 70.1 [9.0] | 70.0 [10.8] | 71.3 [7.5] | 69.8 [8.2] | 69.4 [12.3] | 0.900 |
*
Significant difference.