Figure 5.

Binding of NMV to MPro^1-304/C145Aand structural comparison with MPro^WT. A, superposition MPro^1-304/C145A-NMV complex (colored as yellow-orange cartoon and yellow carbons) on MPro^WT-NMV complex structures obtained at room- and cryo-temperatures with PDB IDs 7SI9 (colored as smudge-green cartoon and green carbon atoms) and 8DZ2 (colored as purple cartoon and carbon atoms), respectively. B, hydrogen bonding and unconventional F…O interactions made by NMV. C, superposition of MPro^1-304/C145A-NMV complex on MPro^WT (PDB ID 7JUN). MPro^1-304/C145A is colored light pink (cartoon) and green/yellow carbon atoms. MPro^WT is colored light orange (cartoon) and orange carbon atoms. Distances are shown in Å.