Table 2.
The effects of genistein on cardio toxicity.
| Study Design | Doses | Route of administration | Effects | Ref |
|---|---|---|---|---|
| Adult rat ventricular myocytes | 20 microM | Dietary intake | ↓Glucose toxicity-induced cardiac mechanical dysfunction | [38] |
|
| ||||
| Guinea pig model | — | Chronic: daily subcutaneous injection for 10 days Acute: intraperitoneal injection 1 hour before endotoxic shock |
↑plasma nitrate concentration ↑cGMP ↓APD |
[39] |
|
| ||||
| Mice | 5 mg/kg | Injection | ↓Expressions of IL-6, IL-8, TNF-α ↑Protein expressions of HO-1, Nrf-2, NQO1 ↓Apoptosis |
[40] |
|
| ||||
| Diabetic rats | 300 mg/kg/day | Administered po for 24 weeks | ↓Blood glucose ↓HbA1c ↓C-reactive protein ↓Expression of TNF-α ↓TGF-β1 proteins ↑Total antioxidant |
[41] |
|
| ||||
| Mice | (0.25, 0.5 or 1 mg/kg) | intraperitoneal injection | ↓Burn-induced myocardial injury ↑LVEF ↓Lactate dehydrogenase ↓level of creatine kinase ↓Apoptosis ↓Inducible NO synthase ↓NO and superoxide anions production ↑Expression of Hes1 and NICD1 ↓Burn-induced myocardial injury ↓Oxidative/nitrative stress |
[42] |