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. 2023 Apr 10;10(16):2207458. doi: 10.1002/advs.202207458

Figure 5.

Figure 5

Reduced OTUD6B predicts a poor prognosis in ESCC patients. A) The expression of OTUD6B and SNAIL in 85 paired ESCC and adjacent normal tissues was detected by immunohistochemistry, and B) the relative expression of OTUD6B was analyzed. Paired t‐test, *** p < 0.001. C) The expression of OTUD6B is positively correlated with β‐TrCP and D) negative correlated with SNAIL in ESCC samples. Pearson's test. E) The expression of OTUD6B in 128 ESCC tissues was detected by immunohistochemistry, and F) stratified by tumor pathological stage or G) lymph node metastasis. unpaired t‐test, **** p < 0.0001. H) Kaplan‐Meier plot of disease‐free survival and I) overall survival of 128 ESCC patients stratified by OTUD6B expression. Two‐sided log‐rank test. J) Kaplan‐Meier plot of the overall survival of ESCC patients stratified by OTUD6B expression using the PRJCA004501 datasets. Two‐sided log‐rank test.