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Reagents and conditions: a isobutyrohydrazide, DIEA, DCM, 23 °C, 30 min, 94% yield; b Lawesson’s Reagent, toluene, 100 °C, 12 h, 96% yield; c zinc powder (100 mesh), NH4Cl, EtOH, 0 °C – reflux, 6 h, 93% yield; d 6, MeCN, 75 °C, 30 min, then 4-(N-Boc amino)-piperidine, DIEA, 75 °C, 30 min, 33% yield; e TFA, ClCH2CH2Cl, room temperature, 3 h, 81% yield
