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. 2023 Jun 3:1–7. Online ahead of print. doi: 10.1007/s00044-023-03079-x

Table 1.

SAR studies: effect of varying the heterocyclic side chain

graphic file with name 44_2023_3079_Taba_HTML.gif
Compound Aryl-R IC50a nM (±SD)
2 graphic file with name 44_2023_3079_Tabb_HTML.gif 57 (±9)
9 graphic file with name 44_2023_3079_Tabc_HTML.gif 54 (±38)
10 graphic file with name 44_2023_3079_Tabd_HTML.gif 100 (±71)
11 graphic file with name 44_2023_3079_Tabe_HTML.gif 210 (±26)
12 graphic file with name 44_2023_3079_Tabf_HTML.gif 21 (±11)
13 graphic file with name 44_2023_3079_Tabg_HTML.gif 10 (±7.1)
14 graphic file with name 44_2023_3079_Tabh_HTML.gif 22 (±13)
15 graphic file with name 44_2023_3079_Tabi_HTML.gif 15 (±7.2)
16 graphic file with name 44_2023_3079_Tabj_HTML.gif 16 (±3.6)
17 graphic file with name 44_2023_3079_Tabk_HTML.gif 11 (±6.2)
18 graphic file with name 44_2023_3079_Tabl_HTML.gif 7.9 (±5.8)
19 graphic file with name 44_2023_3079_Tabm_HTML.gif 770 (±100)

aAAK1 IC50 values are means of two or more experiments, standard deviation is given in parentheses