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Plasma and brain exposures of Compounds 19 and 30 from mouse formalin model taken 90 min post-dose
| Compound 19 and 30 - Mouse Formalin Exposure Data (90 min post-dose) | |||||
|---|---|---|---|---|---|
| Compound | Dose (mg/kg), route | Total Plasma (μM) | Free Plasma (nM) | Total Brain (μM) | B/P |
| 19 | 30, i.p. | 8.4 ± 1.5 | 118 | 1.84 ± 1.84 | 0.22 |
| 30 | 10, s.c. | 2.5 ± 2.1 | 13 | 0.04 ± 0.03 | 0.03 |
| 30, s.c. | 5.4 ± 1.1 | 27 | 0.06 ± 0.02 | 0.01 | |
| 60, s.c. | 11.9 ± 1.2 | 60 | 0.15 ± 0.03 | 0.01 | |
