Table 2.

Epitope mapping and characterization of mAbs.

MAb (K7-)	Total number	S1 (D614G)	eRBD	eRBD (N501Y)	eRBD (E484K)	S B.1.1.529	S BA.5	Epitope
84, 90, 101, 108, 119, 148, 183, 184, 185	9	+	+	+	+	+	+	R12
212, 216	2	+	+	+	+	-	-	R12
62, 82	2	-	+	+	+	-	-	R12
159	1	+	+	-	-	+	+	R6
149	1	+	+	-	-	+	+	R16
150	1	+	+	-	-	-	-	R16
64, 65, 67, 80, 83, 85, 87, 103, 105, 106, 112, 125, 129, 132, 138, 140, 141, 144, 154, 155, 156, 168, 174, 186, 198, 200, 201, 202, 209, 210, 215	31	+	+	-	-	+	+	un
166	1	+	+	-	-	+	-	un
187	1	+	+	-	-	-	-	un
63, 68, 69, 72, 73, 74, 76, 78, 86, 88, 89, 91, 94, 97,99, 102, 104, 107, 109, 113, 115, 121, 124, 126, 127, 130, 131, 134, 135, 136, 145, 146, 151, 161, 164, 165, 167, 171, 176, 178, 179, 180, 188, 190, 191, 192, 195, 196, 197, 205, 206, 208, 211	53	+	-	-	-	+	-	un
61, 66, 70, 77, 79, 92, 93, 98, 100, 111, 114, 116, 117, 133, 137, 139, 142, 143, 147, 153, 157, 181, 182, 189, 199, 204, 213	27	+	-	-	-	+	+	un
81, 118, 152, 158, 160, 162, 169, 172, 193, 194, 217	11	+	-	-	-	-	-	un
123, 214	2	-	+	-	-	-	-	un
71, 75, 120, 122, 170, 173, 175, 177, 207	9	-	-	-	-	-	-	un

S1(D614G), mutant SARS-CoV-2 S1(D614G); eRBD, eukaryotic SARS-CoV-2 RBD; eRBD(N501Y), mutant eukaryotic SARS-CoV-2 RBD(N501Y); eRBD(E484K), mutant eukaryotic SARS-CoV-2 RBD(E484K); +, detectable reaction; -, undetectable reaction; R6, ³⁹¹CFTNVYADSFVIRGD⁴⁰⁵. R12, ⁴⁶³PFERDISTEIYQAGS⁴⁷⁷; R16, ⁵¹⁰VVVLSFELLHAPAT⁵²³; Un, undefined.