Table 1.
Comparison of clinical features between different groups
| Group | Diabetes without neuropathy | Diabetes with asymptomatic neuropathy | Diabetes with symptomatic neuropathy | P value |
|---|---|---|---|---|
| Case (male/female) | 134/116 | 65/60 | 81/69 | 0.940 |
| Age (years) | 51.0 ± 8.6 | 51.2 ± 8.2 | 50.7 ± 7.8 | 0.889 |
| Disease course (years) | 6.6 ± 3.4 | 7.7 ± 2.9 | 8.7 ± 3.7 | < 0.001 |
| SBP (mmHg) | 123 ± 9 | 121 ± 9 | 122 ± 9 | 0.141 |
| DBP (mmHg) | 69 ± 7 | 70 ± 6 | 70 ± 7 | 0.645 |
| BMI (kg/m.2) | 23.9 ± 1.7 | 24.0 ± 1.7 | 24.0 ± 1.7 | 0.854 |
| FPG (mmol/L) | 8.4 ± 1.4 | 8.2 ± 1.7 | 8.3 ± 1.7 | 0.422 |
| HbA1c (%) | 8.0 ± 1.5 | 8.3 ± 1.4 | 8.3 ± 1.3 | 0.085 |
| TC (mmol/L) | 4.8 ± 0.7 | 4.9 ± 0.6 | 4.8 ± 0.8 | 0.915 |
| LDL-C (mmol/L) | 2.8 ± 0.7 | 2.7 ± 0.9 | 2.7 ± 0.9 | 0.133 |
| HDL-C (mmol/L) | 1.4 ± 0.4 | 1.3 ± 0.4 | 1.4 ± 0.4 | 0.264 |
| ALT (IU/L) | 23 ± 3 | 23 ± 3 | 23 ± 3 | 0.239 |
| AST (IU/L) | 22 ± 3 | 21 ± 4 | 22 ± 4 | 0.168 |
| Vit B12 (pmol/L) | 540 ± 201 | 526 ± 203 | 525 ± 186 | 0.671 |
| PLT (× 10.9/L) | 238 ± 62 | 237 ± 64 | 243 ± 69 | 0.792 |
| DR (%) | 10.8 | 23.2 | 25.3 | < 0.001 |
| UACR (mg/g) | 21.5 ± 3.2 | 21.9 ± 2.8 | 21.4 ± 3.1 | 0.368 |
| eGFR [ml/(min·1.73 m.2)] | 103.9 ± 26.9 | 105.1 ± 29.5 | 99.4 ± 26.7 | 0.169 |
| SUA (umol/L) | 353.2 ± 53.8 | 292.2 ± 70.6 | 265.8 ± 67.1 | < 0.001 |