Table 2.
Microbiologic isolates, sensitivity, treatment and related outcomes in complicated urinary tract infections
| Total | NC-cUTI | CAUTI | p† | |
|---|---|---|---|---|
| Variable | n = 900 | n = 735 | n = 165 | |
| Total isolated germs, n (%) * | 996 | 784 | 212 | |
| Etiologic agent | ||||
| E. coli | 642 (64.2) | 561 (71.6) | 81 (38.2) | < 0.001 |
| Klebsiella | 112 (11.2) | 84 (10.7) | 28 (13.2) | 0.308 |
| Proteus | 70 (7) | 43 (5.5) | 27 (12.7) | < 0.001 |
| Pseudomonas | 40 (4) | 20 (2.6) | 20 (9.4) | < 0.001 |
| Enterobacter | 20 (2) | 13 (1.7) | 7 (4.2) | 0.13 |
| Enterococo | 31 (3.1) | 19 (2.4) | 12 (3.3) | 0.016 |
| Morganella | 15 (1.5) | 7 (0.9) | 8 (3.8) | 0.008 |
| Estafilococo | 8 (0.8) | 5 (0.6) | 3 (1.4) | 0.261 |
| Serratia | 12 (1.2) | 5 (0.6) | 7 (3.3) | 0.002 |
| Citrobacter | 16 (1.6) | 4 (0.5) | 12 (5.7) | < 0.001 |
| Candida | 3 (0.3) | 1 (0.1) | 2 (0.9) | 0.647 |
| Otros | 27 (2.7) | 22 (2.8) | 5 (2.4) | 0.722 |
| Second germ isolated, n (%) ** | 96 (10.7) | 49 (6.7) | 47 (28.5) | < 0.001 |
| Antibiogram sensitivity profile, n (%) * | 996 | 784 | 212 | |
| Natural | 293 (29.4) | 250 (31.9) | 43 (20.3) | 0.001 |
| Penicillinases production | 313 (31.4) | 263 (33.5) | 50 (24.2) | 0.006 |
| ESBL | 178 (17.9) | 148 (18.9) | 30 (14.5) | 0.111 |
| AMPc | 119 (11.9) | 65 (8.3) | 54 (25.5) | < 0.001 |
| Carbapenemases resistance | 38 (3.8) | 21 (2.7) | 17 (8.0) | < 0.001 |
| Others | 55 (5.5) | 37 (4.7) | 18 (8.5) | 0.033 |
| Antibiotic administered, n (%) | ||||
| First-generation cephalosporin | 215 (23,9) | 187 (25.4) | 28 (17) | 0.021 |
| Second-generation cephalosporin | 206 (22,9) | 181 (24.6) | 25 (15.2) | 0.009 |
| Third-generation cephalosporin | 9 (1) | 8 (1.1) | 1 (0.6) | 0.574 |
| Fourth-generation cephalosporin | 18 (2) | 10 (1.4) | 8 (4.8) | 0.004 |
| Ampicillin/sulbactam | 13 (1,4) | 10 (1.4) | 3 (3.1) | 0.748 |
| Piperacillin/tazobactam | 32 (3,6) | 26 (3.5) | 6 (3.6) | 0.951 |
| Ertapenem | 311 (34,6) | 242 (32.9) | 69 (41.8) | 0.027 |
| Meropenem | 21 (2,3) | 16 (2.2) | 5 (3) | 0.512 |
| Carbapenems associated with another antibiotic | 28 (3.1) | 14 (1.9) | 14 (8.5) | < 0.001 |
| Quinolones | 16 (1.8) | 15 (2) | 1 (0.6) | 0.208 |
| Others | 31 (3.4) | 26 (3.5) | 5 (3) | 0.866 |
Acronyms: NC-cUTI, non-catheter-associated urinary tract infection; CAUTI, catheter-associated urinary tract infection; ESBL, extended spectrum betalactamase. †p compares NC-cUTI vs CAUTI. *Calculated according to total isolated germs. **Calculated according to total germ isolates in the same urine culture