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. 2023 Mar 29;31(1):13–27. doi: 10.1007/s40199-023-00458-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A photomicrograph of epididymal white adipose connective tissue sections from all experimental groups immuno-histochemicaly stained with: (I): IGF-1: Control group (A), shows extensive positive cytoplasmic immuno-reaction in most of adipocytes (arrows) and connective tissue (C.T.) cells in between adipocytes (curved arrow). MS group (B) shows mild immuno-reactivity in adipocytes (arrows) and negative immuno-reaction in C.T. cells (curved arrows). MS + Dulaglutide (C) and MS + Resveratrol (D) groups exhibit strong cytoplasmic immuno-reaction in both of adipocytes (arrows) and C.T. cells (curved arrows). (II): TNF-α: Control group (E), expresses minimal cytoplasmic immuno-reaction in adipocytes (arrow) and C.T. cells (curved arrow). In MS group (F), marked TNF-α immuno-reactivity is found in most of adipocytes (arrows) and C.T. cells (curved arrow). MS + Dulaglutide (G) and MS + Resveratrol (H) groups, show mild immuno-reaction in adipocytes (arrows) and C.T. cells (curved arrows) (IGF-1 immuno-stain (A, B, C, D) & TNF-α immuno-stain (E, F, G, H) Scale bar = 20 µm)