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. 2022 Dec 6;13(7):1896–1911. doi: 10.1007/s13346-022-01265-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Accumulation of HA-Man NCs in the liver or tumor, with or without Nanoprimer.™ pre-administration, 24 h after their intravenous injection. A Ex vivo fluorescence signal (average radiant efficiency) from the whole tumor normalized to the signal from the whole liver in the MN/MCA fibrosarcoma murine model is presented as percentage. B Ex vivo fluorescence signal (average radiant efficiency) in the liver, related to the accumulation of HA-Man NCs corrected by milligrams of tissue in healthy mice (statistical comparison was performed using t-test. *(p < 0.05), **(p < 0.01)