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. 2023 Jun 2;14:3192. doi: 10.1038/s41467-023-38831-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic of zebrafish TEAZ. Transgenic casper;mitfa:BRAF^V600E;p53^−/− zebrafish were injected with tumor-initiating plasmids and electroporated to generate BRAF^V600E p53^-/- PTEN^ko melanomas. b UMAP dimensionality reduction plot of melanoma and TME cells. Cell assignments are labeled and colored. c Heatmap of top 15 differentially expressed genes in each melanoma transcriptional cell state. Select genes labeled. d UMAP feature plots showing scaled gene expression of pigmentation genes (tyrp1a, dct, pmela, slc45a2). e Tsoi Melanocytic Program⁴ module scores for cells in each melanoma cell state. Adjusted p values were calculated using Wilcoxon rank-sum test with Holm correction. **** p < 0.0001. f Top 10 enriched GO Biological Processes in melanocytic cluster filtered by multi-level Monte Carlo with Benjamini-Hochberg adjusted p values < 0.05. Pathways are color-coded based on pigmentation or metabolism-related pathways. Figure 1a was created with BioRender.com.