Table 1.
Significantly dysregulated gene pathways in MCR group tumor tissues in gene set enrichment analysis (GSEA).
| Pathway | Genes altered n | NES | NOM P value |
|---|---|---|---|
| GO_REGULATION_OF_AXON_GUIDANCE | 12 | 2.16765 | 0 |
| GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY | 23 | 2.15302 | 0 |
| GO_REGULATION_OF_PEPTIDASE_ACTIVITY | 34 | 2.086 | 0 |
| GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION | 37 | 1.90549 | 0 |
| GO_SEGMENTATION | 10 | 1.88023 | 0 |
| GO_CELL_DEATH | 78 | 1.87438 | 0 |
| GO_CIRCULATORY_SYSTEM_DEVELOPMENT | 90 | 1.78643 | 0 |
| GO_REGULATION_OF_CELL_DIFFERENTIATION | 144 | 1.66515 | 0.001642 |
| GO_NEUROGENESIS | 111 | 1.63112 | 0.001681 |
| GO_REGULATION_OF_CELL_GROWTH | 37 | 1.96798 | 0.00177 |
| GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION | 15 | 2.05911 | 0.001805 |
| GO_REGULATION_OF_CELL_SIZE | 21 | 2.09465 | 0.001835 |
| GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH | 14 | 2.05897 | 0.001873 |
| GO_REGULATION_OF_HYDROLASE_ACTIVITY | 104 | 1.62851 | 0.003356 |
| GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY | 14 | 2.01003 | 0.00349 |
| GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION | 62 | 1.74863 | 0.003534 |
| GO_NEGATIVE_REGULATION_OF_CELL_GROWTH | 19 | 1.98756 | 0.00365 |
| GO_EPITHELIUM_DEVELOPMENT | 86 | 1.70045 | 0.004918 |
| GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY | 13 | −1.7604 | 0.011364 |
| GO_SECRETION | 60 | −1.6249 | 0.015113 |
| GO_LOCOMOTORY_BEHAVIOR | 18 | −1.5275 | 0.049041 |
| KEGG_AXON_GUIDANCE | 26 | 1.9428 | 0 |
| KEGG_HEDGEHOG_SIGNALING_PATHWAY | 9 | 1.76627 | 0.00726 |
| KEGG_HEMATOPOIETIC_CELL_LINEAGE | 8 | 1.58435 | 0.045283 |
| KEGG_PPAR_SIGNALING_PATHWAY | 7 | 1.52438 | 0.047438 |