Fig. 4. The promoters of OXPHOS genes contain DNA binding motifs of multiple transcription factors.

a Motif occurrence analysis in promoters of OXPHOS genes of M1BP and other known OXPHOS transcriptional regulators. Each dot represents a binding motif found for a given factor in OXPHOS gene promoters (n (M1BP) = 80, n (E2F1) = 31, n (Mef2) = 111, n (Pho) = 47, n (Sp1) = 30, n (Ets97D) = 39, n (Cnc) = 57, n (CrebB) = 43, n (Ewg) = 37 and n (ERR) = 44 found motifs). The mean and standard deviation of –log10 (p-value) for each OXPHOS gene bound by a given factor is represented. p values, obtained using FIMO¹¹³, are defined as the probability of a random sequence of the same length as the motif matching that position of the sequence with a score at least as good. b Motif co-occurrence analysis in promoters of OXPHOS genes of M1BP and other known OXPHOS transcriptional regulators, represented as a matrix, where each value corresponds to the number of genes bound by a single factor or in combination.