Table 3:
Characteristics and results of CSF analysis in patients with D-CAA and controls.
| Presymp D-CAA (n=10) | Young controls (n=26) | Symptomatic D-CAA (n=12) | Old controls (n=28) | p-value Presymp vs Young | p-value Symp vs Old | p-value Presymp vs Symp | |
|---|---|---|---|---|---|---|---|
| Age (years) | 40±8 | 43±8 | 59±8 | 58±8 | 0.37a | 0.88a | <0.0001a |
| Sex, M/F (n) | 7/3 | 15/11 | 7/5 | 11/17 | 0.50b | 0.27b | 0.18b |
| Hypertension (%) | 20% | 8%c | 33% | 19%d | 0.31b | 0.34b | 0.48b |
| Aβ38 (pg/ml) | 1240 [1043–1701] | 3647 [3196–4833] | 747 [667–1087] | 3387 [2594–4318] | <0.0001e | <0.0001e | 0.14e |
| Aβ40 (ng/ml) | 2.34 [1.88–3.34] | 9.71 [7.12–11.2] | 1.55 [1.17–2.07] | 10.2 [6.52–12.2] | <0.0001e | <0.0001e | 0.047e |
| Aβ42 (pg/ml) | 108 [86.0–148] | 903 [643–1087] | 70.5 [53.3–89.8] | 782 [597–1300] | <0.0001e | <0.0001e | 0.026e |
| Aβ43 (pg/ml) | 9.77 [7.49–12.64] | 63.4 [48.9–63.4] | 6.53 [4.95–8.07] | 47.3 [35.4–68.5] | <0.0001e | <0.0001e | 0.14e |
Table 3: Values are medians and [IQR] except for age (mean ± SD), sex (n), and hypertension prevalence (%).
a
Student’s t-test.
b
Fisher’s exact test,
c
hypertenson status unknown of 1 control,
d
hypertension status unknown of 2 controls,
e
linear regression with age and sex as covariates.
Abbreviations: Aβ= Amyloid beta, CAA= cerebral amyloid angiopathy, F= Female, IQR= interquartile range, M= Male, MoCA: Montreal Cognitive Assessment, presymp D-CAA= patients with presymptomatic D-CAA patients, symp D-CAA=symptomatic D-CAA patients, SD=standard deviation.