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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Mol Cancer Res. 2023 Jun 1;21(6):511–524. doi: 10.1158/1541-7786.MCR-22-1008

Table 2. OncomiR and tumor-suppressor microRNAs in liposarcoma.

Table reporting the most relevant microRNAs acting either as oncogene or tumor-suppressor in the context of liposarcoma with their target genes and regulated biological functions.

microRNA microRNA type Targets Regulated function LPS subtype Reference
miR-155 oncomiR CK-1α Cell cycle DDLPS Zhang P, et al. Cancer Res. 2012.
miR-26a-2 oncomiR RCBTB1, HOXA5 Cell proliferation, Apoptosis, Migration, Cellular differentiation WD/DDLPS Lee DH, et al. Oncogenesis. 2013
Lee DH, et al. Sci Rep. 2015.
miR-143 Tumor-suppressor BCL2, PLK1, PRC1 Cell proliferation, Apoptosis, DDLPS Ugras S, et al. Cancer Res. 2011.
miR-145 Tumor-suppressor - Cell cycle, Cell proliferation, Apoptosis WD/DDLPS Gits CM, et al. Int J Cancer. 2014.
miR-451 Tumor-suppressor - Cell cycle, Cell proliferation, Apoptosis WD/DDLPS Gits CM, et al. Int J Cancer. 2014.
miR-193b Tumor-suppressor FAK, SRC, CRKL, PDGFR, TGFβ, SMAD4, YAP1 Cellular differentiation, Cell proliferation, Apoptosis DDLPS Gits CM, et al. Int J Cancer. 2014.
Mazzu YZ, et al. Sci Rep. 2019.