Table 4. Dysregulated microRNAs in other Soft Tissue Sarcomas.
microRNA | Expression | Target | STS type | Reference |
---|---|---|---|---|
miR-1 | DOWN | CCND2, PAX3 | RMS | Li L, et al. Lab. Investig. 2012. |
miR-143 | DOWN | PRC1, PLK1, BCL2 | SS | Subramanian S, et al. Oncogene. 2008. |
miR-152 | DOWN | MET, KIT | LMS | Pazzaglia L, et al. Cell. Oncol. 2017. |
miR-199b-5p | DOWN UP |
- | LMS UPS |
Guled M, et al. Genes Chromosom. Cancer. 2014. |
miR-206 | DOWN | CCND2, PAX3, PAX7, MET, NOTCH3 | RMS | Li L, et al. Lab. Investig. 2012. Taulli R, et al. JCI. 2009. Missiaglia E, et al. Br J Cancer. 2010. Hanna J.A, et al Cell Death & Disease. 2016. |
miR-221 | DOWN | CCND2, CDK6, ERBB3 | RMS | Hanna J.A, et al. Oncogene. 2018. |
miR-29 | DOWN | CCND2, PAX3, E2F7, MMP2 | FS RMS |
Kim J.H, et al. Chonnam Med. J. 2017. |
miR-29c | DOWN | MMP2 | MPNST | Presneau N, et al. Br J Cancer. 2013. |
miR-30d | DOWN | KPNB1 | MPNST | Zhang P, et al. J. Pathol. 2014. |
miR-340 | DOWN | SIRT7 | AS | Wang X, et al. Biomed Pharmacother. 2018. |
miR-34a | DOWN | - | MPNST | Subramanian S, et al. J. Pathol. 2010. |
miR-378a-3p | DOWN | IGF1R | RMS | Megiorni F, et al. BMC Cancer. 2014. |
miR-497-5p | DOWN | KCa3.1 | AS | Chen Y, et al. Oncotarget. 2016. |
miR-17 | UP | CDKN1A | SS | Minami Y, et al. Cancer Sci. 2014. |
miR-183 | UP | EGR1, PTEN | RMS SS |
Sarver A.L. et al. Cancer Res. 2010. |
miR-21 | UP | PDCD4 | MPNST | Itani S, et al. J Cancer Res Clin Oncol. 2012. |
miR-27a | UP | RARA, RXRA | RMS | Tombolan L, et al. PLoS ONE. 2015. |
miR-320a | UP DOWN |
- | LMS UPS |
Guled M, et al. Genes Chromosom. Cancer. 2014. |
miR-373 | UP | SIRT1, mTOR | FS | Liu P, et al. J. Cell Physiol. 2012. |
miR-486-5p | UP | - | RMS | Hanna J.A, et al. Oncogene. 2018. |
miR-520c | UP | SIRT1, mTOR | FS | Liu P, et al. J. Cell Physiol. 2012. |
miR-9-5p | UP | - | RMS | Missiaglia E, et al. Cancer Letters. 2017. |