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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Dev Dyn. 2023 Feb 9;252(6):691–712. doi: 10.1002/dvdy.567

FIGURE 3. Gene expression profiles across developmental stages for human cardiolipin synthase and tafazzin. (https://apps.kaessmannlab.org/evodevoapp/, accessed 02/24/2022).

FIGURE 3.

A & B) Panel A shows data for cardiolipin synthase (CRLS1). Panel B shows data for tafazzin (TAZ, now known as TAFAZZIN). The human developmental stages include 4 weeks post-conception through adulthood. Panels A & B illustrate key features of these two key enzymes in the cardiolipin biosynthetic pathway: Gene expression profiles that are both stage- and tissue-dependent.

C) The developmental changes in CRLS1 expression in the human heart are enlarged in Panel C, to illustrate more clearly the time scale during prenatal development and postnatal maturation. Major developmental milestones are shown: Cardiogenesis, prenatal growth, newborn, infant-juvenile, and adult.