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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Cancer Prev Res (Phila). 2023 Jun 1;16(6):321–332. doi: 10.1158/1940-6207.CAPR-22-0384

Figure 2. Metabolic analysis of suberoylanilide hydroxamic acid (SAHA) treated on lipopolysaccharide (LPS)-challenged BEAS-2B cells.

Figure 2.

(A) Cell viability of BEAS-2B cells treated with SAHA and challenged with 1 μg/mL LPS; (B) Principal component analysis (PCA) plot of metabolites after SAHA treatment for 3 and 24 h; (C) Significant enrich pathway analysis; (D) Heatmap of metabolites associated with nicotinate and nicotinamide pathway, methionine metabolism, and glutathione pathway after 3 h treatment; (E) Heatmap of metabolites associated with nicotinate and nicotinamide pathway, methionine metabolism, and glutathione pathway after 24 h treatment. All experiments were conducted in triplicate (n = 3).