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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Cancer Prev Res (Phila). 2023 Jun 1;16(6):321–332. doi: 10.1158/1940-6207.CAPR-22-0384

Figure 3. The treatment of suberoylanilide hydroxamic acid (SAHA) promotes the transfer of the methyl group from methionine to methyl nicotinamide (MNA) via S-Adenosylmethionine (SAM).

Figure 3.

(A) The stacked bar showing the transfer of methyl group from methionine to MNA via SAM. M+1: one 13C carbon is attached; m+0: no 13C is labeled; (B) Relative abundance of intracellular methionine, SAM, and MNA after SAHA treatment for 3 and 24 h; (C) The pathway relating to transferring the methyl group from methionine to methylnicotinamide. *P < 0.05 indicates statistically significant. All experiments were conducted in triplicate (n = 3).