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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Cancer Prev Res (Phila). 2023 Jun 1;16(6):321–332. doi: 10.1158/1940-6207.CAPR-22-0384

Figure 5. Transcriptomic changes by suberoylanilide hydroxamic acid (SAHA) in lipopolysaccharide (LPS)-challenged BEAS-2B cells.

Figure 5.

(A) PCA plot transcriptomic profiles and Dendrogram of the gene expression profiles clustered by Euclidean distance; (B) MA plots showing DEGs in response to LPS vs. Control group and LPS+SAHA vs. LPS group with a cut-off of p<0.01 and log2(fold change) ≥ 2 or ≤ −2; (C) Venn diagrams comparing the upregulated and downregulated genes in LPS vs. Control group and LPS+SAHA vs. LPS group; (D) Circos plot of top 11 DEGs that appeared in the completely opposite direction in LPS vs. Control group and LPS+SAHA vs. LPS group; (E) Signaling pathway analysis of SAHA by IPA. RNA samples in all groups (n = 1) were pooled from three replicates.