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. 2023 Mar 29;299(6):104661. doi: 10.1016/j.jbc.2023.104661

Figure 1.

Figure 1

The KMT reactions and the 7BS-fold.A, reactions catalyzed by lysine-specific MTases (KMTs). S-adenosylmethionine (AdoMet) acts as methyl donor and is converted to its unmethylated counterpart, S-adenosylhomocysteine (AdoHcy) during the reaction. B, cartoon representation of the 7BS-fold of the KMT METTL21A (218 amino acids). Only the 7BS region (amino acids 68–211) is shown. The β-strands are shown in orange and numbered; α-helices are shown in gray. The structure (PDB: 4LEC) was visualized using PyMOL Molecular Graphics System, Version 2.4.1. (Schrodinger, LLC) (https://pymol.org/). C, schematic representation of the classical 7BS topology. Color code and numbering as in B.