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. 2023 Mar 29;299(6):104661. doi: 10.1016/j.jbc.2023.104661

Figure 2.

Figure 2

Overview anddomain architecture of human 7BS KMTs. The enzymes have been grouped according to the type of substrate they target. The core 7BS domain is shown in green and other domains are colored as indicated. MTS, mitochondrial targeting sequence. Whereas the first MTase domain of METTL13 catalyzes lysine methylation of eEF1A, the second MTase domain (dark blue) is an eEF1A N-terminal MTase. 7BS, seven-β-strand; eEF1A, eukaryotic translation elongation factor 1α; KMT, lysine-specific MTase; METTL, methyltransferase-like; MTase, methyltransferase.