Table 1.

Effects of azoles on CYP450 isoenzymes and transport proteins. (Source: prescribing information. Spanish Agency of Medicines and Medical Devices)

Itraconazole	Potent CYP3A4 inhibitor, P-gp inhibitor and breast cancer resistance protein (BCRP) inhibitor.
Voriconazole	Inhibits CYP2C19, CYP2C9 and CYP3A4 enzymes.
Posaconazole	Potent CYP3A4 inhibitor.
Isavuconazole	Moderate CYP3A4/5 inhibitor, mild CYP2B6 inducer, mild P-gp inhibitor, mild inhibitor of organic cation transporter 2 (OCT2) and UGT.

P-gp: P-glycoprotein. UGT: UDP-glucuronosyltransferase