Table 3.

Connectivity alterations associated with pain severity.

Seed	Resulting regions	MNI X	MNI Y	MNI Z	Cluster size	T	p-FWE
Effect of Neuropathic Pain Severity
Parahippocampal gyrus (posterior division R)	R putamen and amygdala	26	4	−10	366	−6.41	0.0002
Effect of Nociceptive Pain Severity
Thalamus L	R hippocampus, temporal fusiform cortex (anterior and posterior divisions R), inferior temporal gyrus (anterior division R), R amygdala, parahippocampal gyrus (anterior division R)	38	−14	−18	379	−7.29	0.0005
Joint Effect of Neuropathic and Nociceptive Pain Severities
Parahippocampal gyrus (posterior division R)	R angular gyrus, lateral occipital cortex (superior division R), supramarginal gyrus (posterior division R)	56	−56	44	276	−4.94	0.0016
Amygdala L	L superior parietal lobule, supramarginal gyrus (posterior and anterior divisions L)	−38	−50	46	319	6.21	0.0007
Contrast of Neuropathic and Nociceptive Pain Severities
Cingulate gyrus (posterior division)	Intracalcarine cortex R and L, lingual gyrus R and L, cuneal cortex R and L, supracalcarine cortex R and L, cerebellum 6 R, occipital pole L	14	−74	18	1422	−5.39	<0.000001

Positive and negative T-values reflect positive and negative correlation between neuropathic pain severity and connectivity respectively (in the contrast of neuropathic and nociceptive pain severities, negative T-value reflects negative and positive correlation between neuropathic and nociceptive pain severity and connectivity respectively). Laterality is defined as right (R) and left (L). Montreal Neurological Institute (MNI) system coordinates for resulting regions are provided. Significance level was set at p < 0.0024 after family-wise error (FWE) level of p < 0.05 and additional Bonferroni correction for multiple comparisons across all seed ROIs (21 comparisons) and a minimum of 10 contiguous voxels in resulting clusters.