Table 1.

Mean diameter of ION@Dex, ION@PVA, and ION@PLGA determined via TEM and of XRD data with the Scherrer equation. For ION@PLGA the Scherrer diameter could not be calculated because the thick coating leads to small reflexes even with intense measurement time. IEPs of ION@Dex, ION@PVA, and ION@PLGA. Hydrodynamic diameters of BIONs, ION@Dex, ION@PVA, and ION@PLGA in SBF and human blood plasma at 37 °C.

Particles	TEM diameter dTEM [nm]	Scherrer diameter dScherrer [nm]	Isoelectric point (IEP)	Hydrodynamic diameters in SBF [nm]	Hydrodynamic diameters in human blood plasma [nm]
BIONs				1905 ± 345	326 ± 17
ION@Dex	10.5 ± 2.1	8.6 ± 0.5	6.9	1416 ± 684	238 ± 18
ION@PVA	10.6 ± 2.1	8.8 ± 1.6	7.4	211 ± 7	238 ± 15
ION@PLGA	9.5 ± 2.1	–	2.9	841 ± 81	133 ± 1