Table S7. List of DEG in Herboheal-exposed S. aureus satisfying the dual criteria of log fold-change ≥2 and FDR≤0.01.
| No. | Feature ID/ Gene | Codes for | log fold change | FDR | Up- or down- regulation |
|---|---|---|---|---|---|
| 1 | sarT | HTH-type transcriptional regulator SarT | 18.00 | 0.005 | ↑ |
| 2 | SAFDA_1030 | Alpha-hemolysin | 17.35 | 0 | ↓ |
| 3 | SAFDA_1326 | Hypothetical protein | 11.00 | 0.003 | ↓ |
| 4 | SAFDA_0523 | Hypothetical protein | 10.00 | 0.006 | ↓ |
| 5 | SAFDA_0033 | Hypothetical protein | 8.50 | 0.01 | ↑ |
| 6 | hlgA | Gamma-hemolysin component A precursor | 7.16 | 2.45E-14 | ↓ |
| 7 | SAFDA_1218 | Sensor histidine kinase | 6.91 | 8.32E-07 | ↓ |
| 8 | SAFDA_1829 | Truncated beta-hemolysin | 6.75 | 0.003 | ↓ |
| 9 | SAFDA_0271 | Pyrimidine nucleoside transporter (nupC) | 6.16 | 2.27E-06 | ↑ |
| 10 | SAFDA_1022 | Fibrinogen binding-related protein | 6.00 | 6.10E-05 | ↓ |
| 11 | SAFDA_1441 | Competence protein ComGA | 6.00 | 0.007 | ↑ |
| 12 | SAFDA_2337 | Hypothetical protein | 5.87 | 0 | ↓ |
| 13 | hlgB | Gamma-hemolysin component B precursor | 5.83 | 4.33E-15 | ↓ |
| 14 | SAFDA_0231 | Hypothetical protein | 5.50 | 0.01 | ↑ |
| 15 | SAFDA_1217 | ABC transporter permease | 5.44 | 0.0002 | ↓ |
| 16 | acuA | Acetoin utilization protein | 4.80 | 0.01 | ↓ |
| 17 | icaR | Intercellular Adhesin Locus Regulator | 4.80 | 0.01 | ↓ |
| 18 | ureA | Urea catabolic process | 4.80 | 0.01 | ↑ |
| 19 | SAFDA_0372 | Hypothetical protein | 4.67 | 0.001 | ↓ |
| 20 | SAFDA_1187 | Hypothetical protein | 4.60 | 0.007 | ↑ |
| 21 | saeP | Auxillary protein | 4.26 | 1.77E-07 | ↓ |
| 22 | SAFDA_0127 | Hypothetical protein | 4.25 | 0.004 | ↑ |
| 23 | SAFDA_2543 | Hypothetical protein | 4.13 | 2.77E-06 | ↑ |
| 24 | saeR | two-component system, OmpR family, response regulator | 4.10 | 1.68E-07 | ↓ |
| 25 | SAFDA_0843 | HAD superfamily hydrolase | 4.00 | 0.0006 | ↓ |
| 26 | glpQ | Glycerophosphoryldiesterphosphodiesterase | 3.85 | 0.0009 | ↓ |
| 27 | dapB | 4-hydroxy-tetrahydrodipicolinate reductase | 3.71 | 0.01 | ↓ |
| 28 | ureD | urease accessory protein | 3.66 | 6.33E-05 | ↑ |
| 29 | SAFDA_1182 | Phage repressor | 3.64 | 0.004 | ↓ |
| 30 | hlgC | Gamma-hemolysin component C precu | 3.63 | 4.79E-08 | ↓ |
| 31 | modC | molybdenum transport protein | 3.57 | 1.41E-05 | ↑ |
| 32 | SAFDA_1138 | 50S ribosomal protein L7 | 3.54 | 0.002 | ↓ |
| 33 | saeS | Two-component system, OmpR family, sensor histidine kinase | 3.47 | 3.31E-10 | ↓ |
| 34 | secG | Preproteintranslocase subunit | 3.44 | 0.001 | ↓ |
| 35 | splA | Serine protease | 3.44 | 0.001 | ↓ |
| 36 | sbi | Immunoglobulin G-binding protein Sbi | 3.43 | 1.02E-09 | ↓ |
| 37 | SAFDA_0853 | Hypothetical protein | 3.38 | 0.003 | ↓ |
| 38 | SAFDA_0003 | S4 region YaaA family protein | 3.33 | 0.002 | ↓ |
| 39 | SAFDA_1229 | Hypothetical protein | 3.33 | 0.01 | ↓ |
| 40 | trpA | Tryptophan synthase alpha chain | 3.33 | 0.01 | ↑ |
| 41 | SAFDA_1219 | Two-component response regulator | 3.26 | 6.13E-06 | ↓ |
| 42 | SAFDA_0085 | Hypothetical protein | 3.22 | 0.001 | ↑ |
| 43 | SAFDA_0794 | Hypothetical protein | 3.22 | 0.001 | ↑ |
| 44 | SAFDA_0277 | Hypothetical protein | 3.18 | 0.002 | ↑ |
| 45 | SAFDA_1494 | HAD superfamily hydrolase | 3.14 | 0.005 | ↓ |
| 46 | SAFDA_1538 | Hypothetical protein | 3.13 | 0.004 | ↑ |
| 47 | SAFDA_0193 | Hypothetical protein | 3.05 | 0 | ↓ |
| 48 | SAFDA_0562 | Hydrolase | 2.93 | 0.007 | ↓ |
| 49 | SAFDA_1410 | Hypothetical protein | 2.93 | 2.62E-07 | ↓ |
| 50 | SAFDA_2187 | Phosphosugar-binding transcriptional regulator | 2.92 | 0.01 | ↑ |
| 51 | SAFDA_t0025 | tRNA-Cys | 2.88 | 0.007 | ↓ |
| 52 | spsB | signal peptidase I | 2.88 | 0.007 | ↓ |
| 53 | SAFDA_0228 | Choloylglycine hydrolase | 2.87 | 0.007 | ↑ |
| 54 | glpP | Glycerol uptake operon antiterminator regulatory protein | 2.85 | 0.01 | ↑ |
| 55 | lukG | leukocidin/hemolysin toxin family protein | 2.80 | 9.14E-06 | ↓ |
| 56 | SAFDA_2043 | Hypothetical protein | 2.78 | 6.55E-10 | ↓ |
| 57 | SAFDA_r0007 | 5S ribosomal RNA | 2.71 | 0 | ↑ |
| 58 | coaE | dephospho-CoA kinase | 2.71 | 0.0008 | ↑ |
| 59 | SAFDA_0232 | Hypothetical protein | 2.71 | 0.01 | ↑ |
| 60 | pnp | Polyribonucleotide nucleotidyltransferase | 2.71 | 4.39E-08 | ↑ |
| 61 | SAFDA_2297 | Hypothetical protein | 2.66 | 0.01 | ↑ |
| 62 | SAFDA_2405 | MmpL efflux pump | 2.66 | 9.41E-09 | ↑ |
| 63 | SAFDA_0565 | Alpha/beta fold family hydrolase | 2.66 | 6.40E-11 | ↑ |
| 64 | SAFDA_2223 | ABC transporter permease | 2.64 | 0.01 | ↑ |
| 65 | SAFDA_0423 | Orn Lys Arg decarboxylase family protein | 2.63 | 1.62E-08 | ↑ |
| 66 | SAFDA_2221 | Hypothetical protein | 2.63 | 0.008 | ↑ |
| 67 | tagX | glycosyltransferase | 2.58 | 0.002 | ↓ |
| 68 | sraP | Serine-rich adhesin for platelets | 2.55 | 7.48E-10 | ↑ |
| 69 | SAFDA_2160 | Transcription regulator | 2.55 | 0.0003 | ↑ |
| 70 | SAFDA_0932 | Hypothetical protein | 2.53 | 1.10E-05 | ↓ |
| 71 | SAFDA_1828 | Truncated cell surface protein map-w | 2.52 | 7.00E-07 | ↓ |
| 72 | saeQ | transmembrane protein | 2.47 | 0.001 | ↓ |
| 73 | drm | Phosphopentomutase | 2.45 | 0 | ↑ |
| 74 | SAFDA_0392 | Cobalamin synthesis protein | 2.45 | 0.01 | ↑ |
| 75 | SAFDA_2310 | Amino acid transporter | 2.43 | 0.008 | ↑ |
| 76 | SAFDA_2453 | 2-dehydropantoate 2-reductase | 2.43 | 0.002 | ↑ |
| 77 | sarA | Transcriptional regulator SarA | 2.43 | 2.11E-07 | ↑ |
| 78 | SAFDA_1135 | Hypothetical protein | 2.43 | 0.003 | ↓ |
| 79 | nreA | NreA protein; GAF domain containing protein | 2.41 | 0.005 | ↓ |
| 80 | gcvH | Glycine cleavage system H protein | 2.33 | 0.0004 | ↓ |
| 81 | sdaAB | L-serine dehydratase | 2.32 | 0.006 | ↓ |
| 82 | recQ_1 | ATP-dependent DNA helicase RecQ | 2.32 | 4.68E-06 | ↑ |
| 83 | SAFDA_2273 | Polar amino acid ABC transporter ATPase | 2.31 | 0.003 | ↓ |
| 84 | icaA | intercellular adhesion (ica) locus | 2.30 | 0.009 | ↑ |
| 85 | SAFDA_0225 | Ribose transcriptional repressor RbsR | 2.28 | 0.001 | ↑ |
| 86 | SAFDA_2537 | Lipoprotein, putative | 2.26 | 0.01 | ↑ |
| 87 | rpsO | Small subunit ribosomal protein S15 | 2.26 | 9.03E-06 | ↓ |
| 88 | SAFDA_1759 | Sugar ABC transporter ATPase | 2.26 | 2.72E-07 | ↓ |
| 89 | SAFDA_0987 | Hypothetical protein | 2.25 | 0.009 | ↓ |
| 90 | SAFDA_2261 | Transcriptional regulator NirR | 2.25 | 0.009 | ↓ |
| 91 | SAFDA_0998 | Iron-regulated heme-iron binding protein | 2.25 | 0.001 | ↑ |
| 92 | SAFDA_1045 | HAD superfamily hydrolase | 2.25 | 0.009 | ↑ |
| 93 | xerC | Integrase/recombinase | 2.24 | 0.005 | ↓ |
| 94 | SAFDA_2230 | Glycosylglycerophosphatetransferase involvedin teichoic acid biosynthesis | 2.22 | 0.003 | ↑ |
| 95 | pheT | Phenylalanine--tRNA ligase beta subunit | 2.22 | 1.75E-07 | ↑ |
| 96 | SAFDA_2057 | Alcohol dehydrogenase | 2.21 | 5.04E-08 | ↑ |
| 97 | SAFDA_0091 | Major facilitator transporter | 2.21 | 6.48E-14 | ↑ |
| 98 | tcaB | teicoplanin-associated operon | 2.20 | 0.001 | ↑ |
| 99 | dra | Deoxyribose phosphate aldolase | 2.19 | 5.62E-11 | ↑ |
| 100 | SAFDA_1716 | Hypothetical protein | 2.18 | 0.006 | ↓ |
| 101 | Dps | General stress protein 20U | 2.17 | 0 | ↓ |
| 102 | SAFDA_2462 | Hypothetical protein | 2.14 | 0.007 | ↑ |
| 103 | SAFDA_0189 | ABC transporter substrate-binding protein | 2.11 | 0.009 | ↑ |
| 104 | Geh | Glycerol ester hydrolase | 2.11 | 6.59E-06 | ↓ |
| 105 | rpoE | Probable DNA-directed RNA polymerase subunit delta | 2.10 | 0.001 | ↑ |
| 106 | SAFDA_1657 | Aesenical pump membrane protein | 2.10 | 0.005 | ↑ |
| 107 | rpsB | Small subunit ribosomal protein S2 | 2.09 | 3.60E-11 | ↓ |
| 108 | SAFDA_2315 | M42 glutamylaminopeptidase, cellulose | 2.04 | 4.16E-10 | ↑ |
| 109 | ureC | Urease subunit alpha | 2.03 | 0.0008 | ↑ |
| 110 | mviM | putative oxidoreductase | 2.02 | 0.01 | ↑ |
| 111 | SAFDA_1331 | Major facilitator superfamily permease | 2.02 | 0.01 | ↑ |
| 112 | dapA | 4-hydroxy-tetrahydrodipicolinate synthase | 2.01 | 0.001 | ↑ |
| 113 | SAFDA_2229 | L-lactate permease | 2.00 | 3.68E-09 | ↓ |
Genes are arranged in decreasing order of Fold Change.