Table III -.

Hubs identified as potential targets from among the up- and down-regulated genes in Herboheal-exposed Staphylococcus aureus

No.	Gene ID	Gene name	Codes for	Function
1	SAXN108_0683	sarA	Transcriptional regulator SarA	Probably activates the development of biofilm by both enhancing the ica operon transcription and suppressing the transcription of either a protein involved in the turnover of PIA/PNAG or a repressor of its synthesis, whose expression would be sigma-B-dependent
2	SAXN108_2673	sbi	Immunoglobulin-binding protein Sbi	Plays a role in the inhibition of both the innate and adaptive immune responses
3	SAXN108_1846	splA	Serine protease SplA	Poorly characterized secreted protein probably involved in virulence
4	SAXN108_0774	saeR	Response regulator transcription factor SaeR	The saeR/S system plays a role in regulating such virulence factors which decrease neutrophil hydrogen peroxide and hypochlorous acid production following S. aureus phagocytosis
5	SAXN108_0773	saeS	Histidine kinase
6	SAXN108_2677	hlgB	Gamma-hemolysin component B precursor	Toxins that seem to act by forming pores in the membrane of the cell; has a hemolytic and a leukotoxic activity
7	SAXN108_2676	hlgC	Gamma-hemolysin component C precursor

PIA = polysaccharide intercellular adhesin; PNAG = poly-N-acetyl-β-(1-6)-glucosamine.