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. 2023 May 13;26(6):106876. doi: 10.1016/j.isci.2023.106876

Table 1.

Baseline characteristics

Characteristics Total (N = 34) TQB2450 1200 mg+anlotinib 10 mg (N = 3) TQB2450 1200 mg+anlotinib 12 mg (N = 31)
Age (years), median (range) 50.0 (32.0, 70.0) 48.0 (48.0, 64.0) 50.0 (32.0, 70.0)
 <65, n (%) 31 (91.2) 3 (100) 28 (90.3)
 ≥65, n (%) 3 (8.8) 0 3 (9.7)
ECOG performance status, n (%)
 0 30 (88.2) 3 (100) 27 (87.1)
 1 4 (11.8) 0 4 (12.9)
Metastatic site, n (%)
 Non-visceral 30 (88.2) 3 (100) 27 (87.1)
 Visceral 20 (58.8) 0 20 (64.5)
Number of metastatic sites, n (%)
 1 6 (17.7) 2 (66.7) 4 (12.9)
 2 13 (38.2) 1 (33.3) 12 (38.7)
 ≥3 15 (44.12) 0 15 (48.4)
Chest wall metastasis, n (%) 10 (29.4) 2 (66.7) 8 (25.8)
Liver metastasis, n (%) 8 (23.5) 0 8 (25.8)
Bone metastasis, n (%) 10 (29.4) 0 10 (32.3)
Lung metastasis, n (%) 12 (35.3) 0 12 (38.7)
Lymph nodes metastasis, n (%) 24 (70.6) 2 (66.7) 22 (71.0)
Pleural effusion metastasis, n (%) 3 (8.8) 0 3 (9.7)
Pericardium metastasis, n (%) 0 0 0

Previous chemotherapy, n (%)

 Anthracyclines 32 (94.1) 3 (100) 29 (93.5)
 Taxanes 31 (91.2) 3 (100) 28 (90.3)
 Platinum 16 (47.1) 2 (66.7) 14 (45.2)
Previous neoadjuvant therapy, n (%) 9 (26.5) 1 (33.3) 8 (25.8)
Previous adjuvant therapy, n (%) 25 (73.5) 3 (100) 22 (71.0)
Number of previous therapy lines
 Median (range) 1 (0, 4) 1 (1, 1) 1 (0, 4)
 0, n (%) 1 (2.9) 0 1 (3.2)
 1, n (%) 26 (76.5) 3 (100) 23 (74.2)
 2, n (%) 4 (11.8) 0 4 (12.9)
 >2, n (%) 3 (8.8) 0 3 (9.7)
PD-L1 expression, n (%)
 Negative 13 (38.2) 1 (33.3) 12 (38.7)
 Positive 6 (17.6) 1 (33.3) 5 (16.1)
 Unknown 15 (44.1) 1 (33.3) 14 (45.2)

ECOG, Eastern Cooperative Oncology Group; PD-L1, programmed cell death-ligand 1. Demographics were summarized with descriptive statistics.