Table 2.
Pooled relative risk and mean likelihood ratios for preeclampsia according to BP cutoffs at <20 weeks gestation based on ACC-AHA BP categories
| Study |
Ref |
RR (95% CI); I2 (95% PI) |
−LR (95% CI) |
+LR (95% CI) |
|---|---|---|---|---|
| Diagnostic threshold: sBP 120 mmHg (and dBP <80 mmHg) | ||||
| Pooled | Normal (<120/80 mmHg) | 3.1 (2.6–4.0); I2=10% (1.1–8.4) |
0.69 (0.54–0.82) | 2.42 (2.07–2.82) |
| Bellad et al,29 2020 | 2.1 (1.7–2.6) | 0.94 (0.92–0.96) | 2.2 (1.73–2.68) | |
| Gonzalez-Valencia et al,32 2020 | 4.1 (1.9–8.9) | 0.55 (0.35–0.89) | 2.63 (1.72–4.02) | |
| Greenberg et al,9 2021 | 3.2 (2.8–3.5) | 0.60 (0.57–0.64) | 2.10 (1.99–2.22) | |
| Qureshi et al,39 2020 | 5.2 (4.1–6.5) | 0.61 (0.54–0.68) | 3.49 (3.04–4.00) | |
| Reddy et al,13 2020 | 3.8 (3.2–4.5) | 0.57 (0.51–0.63) | 2.27 (2.10–2.46) | |
| Rosner et al,40 2019 | 5.9 (2.1–16.0) | 0.39 (0.18–0.82) | 2.52 (1.81–3.50) | |
| Sevene et al,41 2020 | 0.9 (0.3–2.6) | 1.01 (0.90–1.13) | 0.94 (0.37–2.42) | |
| Sutton et al,43 2020 | 2.9 (2.6–3.2) | 0.67 (0.62–0.70) | 2.11 (1.98–2.24) | |
| Diagnostic threshold: sBP 130 mmHg or dBP 80 mmHg | ||||
|---|---|---|---|---|
| Pooled | <130/80 mmHg (normal BP + elevated BP) | 3.6 (2.4–5.6); I2=99% (1.4–9.9) |
0.66 (0.51–0.78) | 2.93 (2.32–3.67) |
| Bellad et al,29 2020 | 0.8 (0.6–0.9) | 0.95 (0.94–0.97) | 2.64 (2.00–3.48) | |
| Bello et al,30 2021 | 8.4 (7.9–8.9) | 0.44 (0.42–0.46) | 4.25 (4.14–4.37) | |
| Darwin et al,8 2021 | 4.7 (3.5–6.3) | 0.56 (0.47–0.66) | 2.98 (2.53–3.50) | |
| Duffy et al,31 2021 | 2.1 (2.0–2.2) | 0.79 (0.77–0.80) | 1.73 (1.69–1.77) | |
| Greenberg et al,9 2021 | 4.3 (3.9–4.8) | 0.67 (0.64–0.70) | 3.37 (3.12–3.64) | |
| Huai et al,35 2021 | 3.1 (2.0–5.0) | 0.36 (0.23–0.55) | 1.35 (1.24–1.46) | |
| McLaren et al,37 2021 | 2.6 (1.7–4.1) | 0.46 (0.32–0.68) | 1.79 (1.43–2.25) | |
| Qureshi et al,39 2020 | 6.0 (4.7–7.5) | 0.68 (0.62–0.75) | 4.71 (3.96–5.61) | |
| Reddy et al,13 2020 | 3.6 (3.0–4.3) | 0.73 (0.69–0.79) | 2.79 (2.46–3.16) | |
| Sabol et al,14 2021 | 4.5 (3.6–5.5) | 0.55 (0.49–0.63) | 3.15 (2.76–3.60) | |
| Sevene et al,41 2020 | 0.5 (0.1–3.3) | 1.03 (0.98–1.10) | 0.46 (0.07–3.25) | |
| Sutton et al,43 2020 | 4.2 (3.8–4.7) | 0.73 (0.70–0.76) | 3.67 (3.35–4.02) | |
| Diagnostic threshold: sBP 140 mmHg or dBP 90 mmHg | ||||
|---|---|---|---|---|
| Pooled | <140/90 mmHg (normal BP + elevated BP + stage 1 HTN) | 5.2 (4.1–6.5); I2=94% (1.7–15.10) | 0.80 (0.69, 0.89) | 5.95 (4.17, 8.12) |
| Bellad et al,29 2020 | 4.8 (3.3–6.9) | 0.98 (0.97–0.99) | 6.38 (3.77–10.79) | |
| Bello et al,30 2021 | 8.3 (7.8–8.8) | 0.73 (0.71–0.74) | 7.66 (7.27–8.07) | |
| Darwin et al,8 2021 | 4.3 (3.2–5.8) | 0.71 (0.63–0.80) | 3.53 (2.80–4.46) | |
| Greenberg et al,9 2021 | 5.6 (5.0–6.3) | 0.75 (0.72–0.78) | 5.49 (4.93–6.12) | |
| Huai et al,35 2021 | 2.9 (2.0–4.1) | 0.45 (0.34–0.60) | 1.61 (1.43–1.81) | |
| McLaren et al,37 2021 | 2.0 (1.4–2.9) | 0.84 (0.73–0.96) | 2.61 (1.41–4.83) | |
| Qureshi et al,39 2020 | 12.7 (9.6–16.8) | 0.88 (0.84–0.92) | 18.82 (12.28–28.83) | |
| Reddy et al,13 2020 | 6.5 (4.8–8.7) | 0.93 (0.90–0.95) | 7.22 (5.17–10.07) | |
| Rosner et al,40 2019 | 4.8 (1.7–13.4) | 0.82 (0.64–1.05) | 4.69 (1.76–12.52) | |
| Sabol et al,14 2021 | 5.3 (4.3–6.5) | 0.67 (0.61–0.73) | 5.24 (4.31–6.36) | |
| Sevene et al,41 2020 | 1.9 (0.3–13.0) | 0.99 (0.93–1.04) | 1.97 (0.26–14.70) | |
| Sutton et al,43 2020 | 5.5 (4.9–6.1) | 0.79 (0.77–0.82) | 5.84 (5.17–6.60) | |
ACC-AHA, American College of Cardiology-American Heart Association; BP, blood pressure; CI, confidence interval; −LR, negative likelihood ratio; +LR, positive likelihood ratio; PI, prediction interval; RR, relative risk.
Slade. The diagnostic accuracy of American College of Cardiology-American Heart Association blood pressure categories for identification of women and babies at risk. Am J Obstet Gynecol 2023.